Fig. 1. FITC-dextran-perfused retinal flat mounts showing retinal vascularization (left column), avascular area (middle column), and neovascular tufts (right column). In the sham-injected group, a distinctive central ischemic area (A, B) and many neovascular tufts were observed (C). However, the area of ischemia was clearly reduced in the low- (D, E) and high-dose (G, H) sulodexide groups. Neovascular tufts were also significantly reduced in the low- (F) and high-dose (I) sulodexide groups.