Table 2.
Variable | Group 1 (n = 10) | Group 2 (n = 10) | Group 3 (n = 10) | P-value* |
---|---|---|---|---|
Body weight (g) | 24.91 ± 1.39 | 25.04 ± 2.32 | 25.08 ± 1.36 | 0.977 |
RBC count (1.0 × 106/mL) | 8.14 ± 0.33a | 10.10 ± 1.05b | 10.12 ± 1.52b | <0.001 |
Hemoglobulin (gm/dL) | 11.83 ± 0.45a | 14.73 ± 1.52b | 14.61 ± 2.27b | <0.001 |
RVSP (mm Hg) | 20.89 ± 1.69a | 39.31 ± 3.37b | 29.57 ± 1.77c | <0.001 |
LVSP (mm Hg) | 103.38 ± 10.48 | 94.96 ± 15.11 | 94.97 ± 15.07 | 0.410 |
RV weight (g) | 0.021 ± 0.012a | 0.028 ± 0.003b | 0.023 ± 0.025a | <0.001 |
Total HW (g) | 0.107 ± 0.404 | 0.127 ± 0.015 | 0.119 ± 0.125 | 0.119 |
Ratio of RV/total HW | 0.178 ± 0.015a | 0.222 ± 0.302b | 0.189 ± 0.018a | <0.001 |
Total lung weight (g) | 0.145 ± 0.009a | 0.193 ± 0.027b | 0.160 ± 0.028a | <0.001 |
Data are expressed as means ± SD.
RBC = red blood cell; RVSP = right ventricular systolic pressure; LVSBP = left ventricular systolic blood pressure; HW = heart weight.
Group 1 = sham control; group 2 = hypoxia + negative control siRNA; group 3 = hypoxia + siRNA-TRPC1.
*By one-way ANOVA.
Different letters (a, b, c) are being used for grouping, showing significant difference (at level 0.05) among different groups by Tukey's multiple comparison procedure.