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Homology models of both human IRS-1 and IRS-1 were retrieved utilizing automated protein modelling options through I-TASSER. The best 3D representative models for both IRS-1 (in red) and IRS-2 (in green) were aligned using FATCAT server and viewed in Chimera software package. Sequence alignment revealed that both proteins are significantly different in structure and only have 4.02% identity and 8.71% similarity.
