Fig. 8.

Blocking tumor cell-associated αvβ3 inhibits pathological angiogenesis in vivo. M21 cells (1.0 × 10⁶) were injected into mice and allowed to grow for 3 days. a Mice were untreated or treated daily with anti-human antibody LM609 on control normal mouse IgG (100 μg). Top panel Examples of blood vessels infiltrating tumors from each condition. Bottom panel Example of tumor tissue from each condition stained by H&E. b Quantification of blood vessels infiltrating tumors from the surrounding skin. Data bars indicate mean number of surface vessels infiltrating the tumors ±SE from 6 tumors from each condition. c Mice were injected with M21 cells (5 × 10⁶) and treated on days 3 and 5 with Mab LM609 or normal mouse IgG (50 lg) and tumors analyzed on day 7. Data bars represent mean tumor volumes ± SE from 5 to 6 mice per condition. d Quantification of blood vessels infiltrating tumors from the surrounding skin. Data bars indicate mean number of surface vessels infiltrating the tumors ±SE from 5 to 6 tumors from each condition. *Indicates P values <0.05