Table I.
Compositions of two separate systems studied: a) lipid drug delivery system dosed in fasted state, b) “food lipid” (soybean oil) in fed state bio-relevant media.
| a) Drug delivery system in fasted state | b) Food lipids in fed state | |||
|---|---|---|---|---|
| Maleate Buffer | pH 6.5 | pH 6.5 | ||
| Trizma® maleate | 100 mM | Trizma® maleate | 100 mM | |
| NaCl | 65 mM | NaCl | 65 mM | |
| CaCl2*2H2O | 5 mM | CaCl2*2H2O | 10 mM | |
| NaN3 | 3 mM | NaN3 | 3 mM | |
| NaOH | 40 mM | NaOH | 40 mM | |
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| Bile salt | NaTDC | 5 mM | NaTDC | 12 mM |
|
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| Phospholipid | Lecithin | 1.25 mM | Lecithin | 4 mM |
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| Ratio BS/PL | 4:1 | 3:1 | ||
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| Lipid Substrate | SEDDS formulation: Soybean oil:Tween 80 1:1 (w/w), 1:100 formulation dilution in fasted state solution | Soybean oil | 50 mM | |