Table III.

Input parameters to the developed models

Input parameters	a) Release from SEDDS	b) Drug dissolution from solid dosage form
Physiological parameters	Value	Value
Bile salt concentration	5×10−3 mmol/ml	12×10−3 mmol/ml
Phospholipid concentration	1.25×10−3 mmol/ml	4×10−3 mmol/ml
Critical micelle concentration (21)	1.6×10−3 mmol/ml	1.6×10−3 mmol/ml
Formulation and drug parameters
Mean droplet diameter of oil emulsions (10)	403 nm	386 nm
Molecular weight of TB	276.35 mg/mmol	276.35 mg/mmol
Number of digestible FA per mole oil emulsion (15)	2	2
Initial concentration of TB in a) formulation volume, b) solution volume	0.02533 mmol/ml	0.003618 mmol/ml
Initial volume ratio of a) formulation, b) oil in intestinal lumen	1:100	4.8:100
Concentration of Tween 80 associated in BS/PL micelles	8.14 mmol/ml	-
(Molar) solubilization of TB in BS/PL micelles	0.2115 mmol/ml	0.2115 mmol/ml
Solubility of TB in buffer (5mM Ca2+/10mM Ca2+)	4.7×10−5 mmol/ml	7.2×10−5 mmol/ml
Solubility of TB in a) fasted, b) fed bio-relevant media	3.4×10−4mmol/ml	4.5×10−4 mmol/ml
Solubility of TB in a) formulation, b) soybean oil	0.579 mmol/ml	0.788 mmol/ml
Stationary diffusion layer, h1	-	20 μm
Particle size of TB2	-	20 μm
Kinetic parameters
Diffusion coefficient of TB, DD	-	8.3743*10−10 m2/s
Diffusion coefficient of micelles, Dm	-	6.5578*10−11 m2/s.
Formulation or oil digestion kinetic constant, kdig	4.7×10−9 mmol/cm2s	3.6×10−9mmol/cm2 s
Formulation or oil digestion inhibition kinetic constant, kinh	2.8×10−4 1/s	4.3×10−4 1/s
a) TB release constant from formulation, b) TB uptake constant into oil, Prel	5.55×10−9 cm/s	3.52×10−8 cm/s

Notes -

¹assumed to be equal to initial particles’ radius (25);

²estimated based on particles’ separation by controlled sieve mesh; all the other parameters were calculated as explained in the text.