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Channel Detection Rate (Pd) of Isoflurane-activated Type 3 InsP3R
| Isoflurane (0.4 mM) | InsP3 (μM) | Heparin (100 μg/ml) | Xestospongin C (μM) | Channel Detection Rate (Pd) | Patches (n) | |
|---|---|---|---|---|---|---|
| Type-3 InsP3R | − | 0 | − | − | 0/14(0) | 14 |
| + | 0 | − | − | 15/85(0.18) | 85 | |
| − | 1 | − | − | 18/20(0.9) | 20 | |
| − | 10 | − | − | 31/34(0.92) | 34 | |
| + | − | + | + | 0/40(0) | 40 | |
| + | − | − | + | 0/40(0) | 40 | |
|
| ||||||
| InsP3R Knockout | − | 10 | − | − | 0/10(0) | 10 |
| + | 0 | − | − | 0/40(0) | 40 | |
InsP3R – inositol 1,4,5-trisphosphate receptors.
