Table II.

Mean frequency and the range of frequencies of rearrangements of core IGHV genes, which were observed in VDJ gene rearrangements of all individuals, and of noncore genes, which were seen in some but not all individuals studied

Core Genes	Mean ± SEM (%)	Range (%)	Noncore Genes	Carriers	Range (%)
IGHV1-2	1.66 ± 0.30	0.3–3.9	IGHV1-f	4	0.1–0.4
IGHV1-3	2.48 ± 0.32	1.2–4.5	IGHV3-13	5	0.01–0.04
IGHV1-8	2.16 ± 0.23	1.1–3.4	IGHV3-19 (P)	9	0.02–0.13
IGHV1-18	3.84 ± 0.27	2.1–5.1	IGHV3-30-3	5	2.6–6.8
IGHV1-24	0.58 ± 0.04	0.4–0.8	IGHV3-35 (ORF)	3	0.01–0.02
IGHV1-45	0.14 ± 0.02	0.1–0.2	IGHV3-43	8	0.04–1.0
IGHV1-46	2.65 ± 0.11	2.0–3.1	IGHV3-47 (P)	9	0.03–0.1
IGHV1-58	0.43 ± 0.04	0–3–0.6	IGHV3-52 (P)	2	0.01–0.02
IGHV1-69	6.16 ± 0.55	3.1–9.7	IGHV4-28	6	0.01–0.07
IGHV2-5	1.46 ± 0.17	0.2–2.3	IGHV4-30-2	7	0.05–1.2
IGHV2-26	0.70 ± 0.06	0.4–1.1	IGHV4-30-4	7	0.03–1.5
IGHV2-70	1.13 ± 0.10	0.7–1.6	IGHV4-61	4	0.6–2.1
IGHV3-7	3.70 ± 0.22	2.4–5.1	IGHV5-a	7	0.04–2.5
IGHV3-9	2.34 ± 0.29	1.1–3.9	IGHV7-4	9	0.04–3.6
IGHV3-11	3.16 ± 0.20	2.3–5.0	IGHV7-81	8	0.01–0.4
IGHV3-15	1.98 ± 0.18	1.2–3.4
IGHV3-20	0.57 ± 0.12	0.1–1.5
IGHV3-21	4.59 ± 0.21	3.5–6.3
IGHV3-22 (P)	0.15 ± 0.02	0.1–0.2
IGHV3-23	8.86 ± 0.61	6.0–13.7
IGHV3-30	5.89 ± 0.71	1.6–10.5
IGHV3-33	4.92 ± 0.45	3.0–7.8
IGHV3-48	3.78 ± 0.33	1.7–5.5
IGHV3-49	1.00 ± 0.05	0.8–1.3
IGHV3-53	1.84 ± 0.16	0.5–2.6
IGHV3-64	0.58 ± 0.10	0.1–1.1
IGHV3-66	1.01 ± 0.16	0.3–1.7
IGHV3-71	0.18 ± 0.03	0.1–0.4
IGHV3-72	0.26 ± 0.02	0.1–0.4
IGHV3-73	0.47 ± 0.04	0.3–0.7
IGHV3-74	1.78 ± 0.11	1.3–2.4
IGHV4-4	1.73 ± 0.24	0.4–2.6
IGHV4-31	2.60 ± 0.34	0.8–4.1
IGHV4-34	4.70 ± 0.52	2.7–9.7
IGHV4-39	4.82 ± 0.46	2.0–8.0
IGHV4-55 (P)	0.07 ± 0.01	0.03–0.2
IGHV4-59	5.76 ± 0.38	3.1–7.6
IGHV5-51	2.01 ± 0.22	0.5–3.0
IGHV6-1	0.80 ± 0.06	0.5–1.1
humIGHV177(P)	0.15 ± 0.02	0.1–0.2
humIGHV181(P)	0.56 ± 0.06	0.4–1.1

Data are presented for the 11 subjects from whom PBMC-derived sequences were obtained. The number of carriers of each noncore gene is also shown. Ps and ORFs are indicated.

P, pseudogene.