Table IV.
Mean frequency and range of alignments to IGHD genes in 11 healthy individuals and in an individual with aplastic anemia
| Mean ± SEM (Healthy Individuals) (%) |
Range (Healthy Individuals) (%) |
AA Sample | |
|---|---|---|---|
| IGHD1-1 | 0.7 ± 0.1 | 0.5–0.8 | 0.5 |
| IGHD2-2 | 7.4 ± 0.8 | 4.3–13.2 | 3.3 |
| IGHD3-3 | 7.8 ± 0.9 | 2.9–11.3 | 0.3 |
| IGHD4-4/4-11a | 1.0 ± 0.1 | 0.5–1.6 | 0.1 |
| IGHD5-5/5-18b | 3.6 ± 0.3 | 2.4–4.4 | 2.9 |
| IGHD6-6 | 3.6 ± 0.4 | 2.1–4.4 | 0.7 |
| IGHD1-7 | 1.0 ± 0.2 | 0.5–1.0 | 0.1 |
| IGHD2-8 | 1.2 ± 0.2 | 0.4–1.6 | 0.2 |
| IGHD3-9 | 3.3 ± 0.4 | 1–8–5.2 | 4.7 |
| IGHD3-10 | 10.5 ± 1.3 | 5.9–15.4 | 20.8 |
| IGHD5-12 | 2.3 ± 0.2 | 1.4–3.0 | 2.4 |
| IGHD6-13 | 7.5 ± 0.5 | 5.5–12.1 | 13.0 |
| IGHD2-15 | 4.9 ± 0.3 | 3.0–5.6 | 3.6 |
| IGHD3-16 | 2.0 ± 0.1 | 1.2–2.8 | 2.2 |
| IGHD4-17 | 5.0 ± 0.3 | 3.6–6.3 | 4.4 |
| IGHD6-19 | 7.6 ± 0.3 | 6.6–9.1 | 11.8 |
| IGHD1-20 | 0.7 ± 0.1 | 4.2–6.9 | 5.6 |
| IGHD2-21 | 2.4 ± 0.1 | 2.1–4.4 | 1.8 |
| IGHD3-22 | 12.2 ± 0.8 | 11.3–14.8 | 13.0 |
| IGHD4-23 | 1.4 ± 0.1 | 0.8–2.1 | 1.5 |
| IGHD5-24 | 2.1 ± 0.1 | 1.8–2.6 | 1.6 |
| IGHD1-26 | 5.1 ± 0.2 | 4.2–6.9 | 5.6 |
| IGHD7-27 | 1.0 ± 0.1 | 0.6–1.7 | 1.4 |
Data for six IGHD genes that may not be present in the genome of the AA patient are in boldface.
a
IGHD4-4 and IGHD4-11 have identical coding regions, but IGHD4-11 is associated with an apparently nonfunctional recombination signal sequence.
b
IGHD5-5 and IGHD5-18 have identical coding regions, and both genes are normally functional. The alignments shown for the AA patient could all use the IGHD5-18 gene.
AA, aplastic anemia.