FIGURE 12.

Network-based approach for linking Oat1-mediated transport to metabolism. A, inset: an integrative computational approach was used to analyze both gene expression data from the kidneys of Oat1 knockout mouse and metabolomics data derived from the plasma and urine of Oat1 knockout animals. Certain predictions based on the comparison of these two separate network analyses are supported by wet-lab data. B: the integrative network-based analyses of a comparison of the wild-type and Oat1-knockout mouse suggested alterations in many metabolic reactions in the Oat1 knockout. Implicated pathways included those involved in nucleotide, fatty acid, carnitine, chondroitin sulfate, inositol phosphate, and biotin metabolism. [From Ahn et al. (4). Copyright the American Society for Biochemistry and Molecular Biology.]