Figure 6.

Steps of cellular uptake and recycling of LDL loaded with drug by LDLRs. Plasma LDL can be cleared from circulation through LDL receptor (LDLR)-mediated endocytosis. This allows for the transfer of LDL into endosomes, where the pH drops, causing LDL to dissociate from the receptor. The receptor is then recycled to the surface of the cell, while LDL is transferred into the lysosomes for degradation. This pathway could be useful for drug delivery, and may then be directed toward tumor cell overexpressing LDLRs.