Table 5.
Top 20 probe sets and their corresponding GO process, upregulated with differentiation in the diabetic subjects compared with the controls and ranked by fold change
| Probe Set ID | Gene Symbol | Fold Change | P Value | GO Biological Process | Secreted? |
|---|---|---|---|---|---|
| 202859_x_at | IL8 | 11.7 | 0.03 | Inflammatory response | Yes |
| 233533_at | KRTAP1-5 | 8.7 | 0.01 | Unknown | |
| 202086_at | MX1 | 7.3 | 0.04 | Defense response | |
| 203001_s_at | STMN2 | 6.1 | 0.04 | Microtubule organization | |
| 202410_x_at | IGF2 | 5.7 | 0.01 | MAPK cascade | Yes |
| 211356_x_at | LEPR | 5.0 | 0.02 | Cytokine-mediated signaling pathway | |
| 201641_at | BST2 | 4.5 | 0.02 | Immune response | |
| 202803_s_at | ITGB2 | 4.5 | 0.0009 | Toll-like receptor signaling pathway | |
| 52837_at | KIAA1644 | 4.2 | 0.01 | Unknown | |
| 204602_at | DKK1 | 4.2 | 0.04 | Wnt receptor signaling pathway | Yes |
| 219602_s_at | PIEZO2 | 3.9 | 0.03 | Ion transport | |
| 204415_at | IFI6 | 3.9 | 0.02 | Cytokine-mediated signaling pathway | |
| 201348_at | GPX3 | 3.8 | 0.04 | Glutathione metabolic process | Yes |
| 209869_at | ADRA2A | 3.7 | 0.04 | Cytokine production | |
| 242871_at | PAQR5 | 3.6 | 0.03 | Cell differentiation | |
| 218469_at | GREM1 | 3.6 | 0.01 | Cell differentiation | Yes |
| 205258_at | INHBB | 3.5 | 0.008 | Defense response | Yes |
| 229450_at | IFIT3 | 3.5 | 0.04 | Cytokine-mediated signaling pathway | |
| 204597_x_at | STC1 | 3.4 | 0.01 | Ca2+ homeostasis | Yes |
| 203698_s_at | FRZB | 3.4 | 0.02 | Wnt receptor signaling pathway | Yes |
GO, gene ontology.
Uncorrected P values were calculated by t-test with equal variance. P < 0.05 was considered significant.