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. 2014 Nov 5;308(1):F69–F75. doi: 10.1152/ajprenal.00484.2014

Fig. 1.

Fig. 1.

High-mobility group box 1 (HMGB1) expression and release in mouse kidneys with unilateral ureter obstruction (UUO). A: HMGB1 expression in kidney tissue on different days [days 0–14 (D0–D14)] after UUO as indicated. HMGB1 expression was detected by immunostaining. B: HMGB1 expression in macrophage was detected by coimmunostaining of HMGB1 with F4/80 on kidney sections with UUO for 5 days. C: HMGB1 expression was quantified by Western blot analysis and normalized to α-tubulin. n = 5. *P < 0.01 compared with D0; #P < 0.01 compared with D3. D: serum HMGB1 concentration as measured by ELISA. n = 5. *P < 0.01 compared with D0; #P < 0.01 compared with D3 or D5 in UUO groups. E: urine HMGB1 concentration as measured by ELISA. n = 5. *P < 0.01 compared with D0; #P < 0.01 compared with D5.