Table 1.
Average potassium and sodium blood levels from 2–3 sheep
| Vehicle, n = 3 |
Compound A, 0.3 mg, n = 2 |
Compound A, 3 mg, n = 2 |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood K+, mM |
Blood Na+, mM |
Blood K+, mM |
Blood Na+, mM |
Blood K+, mM |
Blood Na+, mM |
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| Time Point | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD |
| Predose | 4.4 | 0.7 | 152 | 10 | 4.7 | 0.0 | 149 | 4.0 | 4.3 | 0.1 | 148 | 5.6 |
| Immediate | 4.1 | 0.2 | 150 | 2.3 | 4.3 | 0.1 | 147 | 4.5 | 4.0 | 0.3 | 146 | 0.3 |
| 15 min | 4.2 | 0.3 | 146 | 1.6 | 4.1 | 0.3 | 146 | 0.3 | 4.2 | 0.3 | 145 | 0.3 |
| 30 min | 4.1 | 0.2 | 148 | 4.1 | 4.2 | 0.4 | 149 | 1.5 | 4.3 | 0.4 | 145 | 2.0 |
| 1 h | 3.8 | 0.1 | 151 | 3.5 | 3.9 | 0.3 | 146 | 2.5 | 4.8 | 0.3 | 142 | 0.1 |
| 2 h | 3.7 | 0.4 | 147 | 3.8 | 4.1 | 0.3 | 144 | 0.4 | 5.2 | 0.4 | 141 | 1.9 |
| 4 h | 4.2 | 0.3 | 147 | 3.3 | 3.6 | 0.1 | 144 | 0.1 | 4.3 | 0.5 | 140 | 0.1 |
| 6 h | 4.6 | 0.7 | 147 | 3.4 | 3.9 | 0.3 | 145 | 4.2 | 4.1 | 0.2 | 141 | 0.5 |
| 24 h | 4.9 | 0.5 | 155 | 14.1 | 5.5 | 0.0 | 152 | 4.2 | 5.4 | 0.2 | 146 | 1.7 |
Sheep after having received vehicle (diurnal rhythm of blood electrolytes) or Compound A at 0.3 mg and 3 mg (corresponding to 7.5 and 75 μg/kg) by inhalation. The higher dose indicates increased blood potassium at 1 and 2 h after dosing vs. vehicle controls (explorative statistical analysis only).