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Linopirdine primes hypoxic pulmonary vasoconstriction (HPV) in saline-perfused rat lungs. HPV response measured in unprimed lungs 15, 30, or 65 min after bolus injection of 230 μg linopirdine into the inflow cannula to give an effective concentration of ∼12 μM (gray, n = 6) and in time-matched controls (black, n = 5). *P < 0.05 vs. control.
