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Kv channel inhibition modulates pulmonary vascular responses to hypoxia and angiotensin II in primed lungs. Baseline perfusion pressure (A), angiotensin II-induced vasoconstriction (B), and HPV (C) measured in primed lungs before (control, black bars) and after exposure to 12 μM linopirdine (LNP) or 12 μM linopirdine plus 3 mM 4-aminopyridine (4-AP) (LNP + 4-AP) (gray bars). #P < 0.05 control vs. LNP or LNP + 4-AP, *P < 0.05 LNP vs. LNP + 4-AP; n = 6 for both group. NS, not significant.
