Table 2.

Flupirtine treatment decreases incremental flow resistance and HPV in rats exposed to 5-day hypoxia

Group	P/Q Slope, mmHg·min/ml	P/Q Intercept, mmHg	HPV, Δ mmHg	ANG II Constriction, Δ mmHg	NOx in Plasma, μM
Normoxia	0.541 ± 0.052	3.6 ± 0.7	5.3 ± 1.0	5.6 ± 0.6	26.0 ± 2.5
Hypoxia	0.672 ± 0.05*	3.7 ± 0.4	8.5 ± 1.1*	9.3 ± 1.3*	46.6 ± 8.3*
Hypoxia + flupirtine	0.475 ± 0.022†	5.3 ± 0.5	4.9 ± 1.0†	11.7 ± 1.4*	47.5 ± 2.6*
Hypoxia + vehicle	0.678 ± 0.111*	3.6 ± 1.1	9.6 ± 1.4*	9.0 ± 0.8*	40.0 ± 2.5*

The pressure-flow (P/Q) slope and intercept, amplitude of hypoxic pulmonary vasoconstriction (HPV), and angiotensin II (ANG II) induced vasoconstriction and total plasma concentration of nitric oxide (NO) and its oxidation products (NOx) in rats exposed to normoxic or hypoxic conditions. One group of hypoxic rats also received 30 mg/kg/day flupirtine, while another group had an equivalent volume of vehicle.

^*P < 0.05 vs. normoxia.

^†P < 0.05 vs. hypoxia and hypoxia with vehicle; n = 6 for each group.