AAMP |
binds NOD1 weakly [10] |
|
|
inhibits NF-κB signalling [10] |
|
binds NOD2 [10] |
cytoplasm, plasma membrane [10] |
NACHT, CARDs [10] |
inhibits NF-κB signalling [10] |
|
ATG16L1 |
binds NOD1 [7,11] |
plasma membrane, bacterial entry sites [7] |
CARD [11] |
promotes autophagy [7] |
Crohn's disesase [5] |
BINDS NOD2 [7,11,12] |
plasma membrane, bacterial entry sites [7] |
CARDa [12]; Tandem CARDs [11] |
promotes autophagy [7] |
|
β-PIX |
binds NOD2 [13] |
plasma membrane [13] |
|
membrane recruitment, inhibits IL-8 production [13] |
|
Beclin |
binds NOD2 [14] |
|
|
|
|
BID |
binds NOD1 [15]; binds NOD2 [15] |
|
|
enhances NF-κB and ERK signalling [15] |
|
CAD |
binds NOD1 [16] |
|
|
inhibits NF-κB signalling [16] |
|
binds NOD2 [16] |
|
CARDs [16] |
inhibits NF-κB signalling [16] |
|
CARD8 |
binds NOD2 [17] |
cytoplasm [17] |
NACHT [17] |
inhibits NF-κB signalling [17] |
Crohn's disease [18] |
CARD9 |
binds NOD2 [8] |
|
CARD–NACHT linker, NACHT [9] |
enhances p38 signalling [8] |
Crohn's disease [6] |
Caspase-1 |
binds NOD1 [19] |
|
CARD [19] |
enhances IL-1β secretion [19] |
|
binds NOD2 [20] |
|
Tandem CARDs [20] |
enhances IL-1β secretion [20] |
|
CD147 |
binds NOD2 [21] |
plasma membrane [21] |
Tandem CARDs [21] |
inhibits NF-κB and IL-8 signalling [21] |
|
Centaurin-β1 |
binds NOD1 [22]; binds NOD2 [22] |
cytoplasm [22] |
|
inhibits NF-κB [22] |
|
DUOX2 |
binds NOD2 [23] |
cytoplasm, membrane [23] |
LRR [23] |
enhances NF-κB [23] |
|
Erbin |
does not bind NOD1 [24,25] |
|
|
|
|
binds NOD2 [24,25] |
plasma membrane [24,25] |
CARDs [24] |
inhibits NF-κB [24] |
|
FRMPD2 |
binds NOD2 [26] |
plasma membrane [26] |
LRR [26] |
membrane recruitment, enhances NF-κB [26] |
|
GRIM-19 |
binds NOD2 [27] |
intracellular vesicles [27] |
|
enhances NF-κB [27] |
|
does not bind NOD1 [27] |
|
|
|
|
HSP70 |
binds NOD2 [28] |
|
|
promotes NOD2 stability; enhances NF-κB signalling [28] |
|
HSP90 |
binds NOD1 [29,30] |
|
|
promotes NOD1 stability [29] |
|
binds NOD2 [30,31] |
|
CARDs [31] |
stabilizes NOD2, required for NF-κB signalling [31] |
|
JNKBP1 |
does not bind NOD1 [32] |
|
|
|
|
binds NOD2 [32] |
|
CARDa, LRRs [32] |
inhibits NF-κB and IL-8 signalling [32] |
|
MAVS |
does not bind NOD1 [33] |
|
|
|
|
binds NOD2 [33] |
mitochondria [33] |
NACHT-LRR [33] |
antiviral defence [33] |
|
NIK |
binds NOD2 [34] |
|
NACHT-LRR [34] |
enhances non-canonical NF-κB signalling [34] |
|
NLRC4 |
binds NOD1 [35] |
|
NACHT [35] |
inhibits NF-κB [35] |
|
binds NOD2 [36,35] |
|
CARD [36], NACHT [35] |
inhibits NF-κB [35] |
|
NLRP1 |
binds NOD2 [20,37] |
|
CARDs [37] |
enhances IL-1β secretion [20] |
Crohn's disease [38] |
NLRP3 |
binds NOD2 [37] |
|
CARDs [37] |
|
Crohn's disease [38] |
NLRP12 |
binds NOD2 [37] |
|
CARDs [37] |
|
|
OAS2 |
binds NOD2 [39] |
|
|
enhances RNase-L function [39] |
|
Rac1 |
binds NOD2 [13,40] |
plasma membrane [13,40] |
CARDS, LRR [40] |
membrane recruitment [13,40] |
|
RIG-I |
binds NOD2 [41] |
membrane ruffles [41] |
|
inhibits NF-κB signalling [41] |
|
RIP2 |
binds NOD1 [19] |
|
CARD [19] |
required for NF-κB signalling [42] |
|
binds NOD2 [1] |
plasma membrane [43] |
CARDs [1] |
required for NF-κB signalling [42] |
|
SGT1 |
binds NOD1 [44,30] |
|
LRR [44] |
enhances NF-κB and JNK signalling [44] |
|
binds NOD2 [44,30] |
|
|
no effect on NF-κB or JNK signalling [44] |
|
SLC15A3/4 |
binds NOD2 [45] |
endosomal membrane [45] |
|
enhances NF-κB signalling [45] |
|
SOCS-3 |
binds NOD2 [31] |
|
CARDs [31] |
NOD2 degradation [31] |
|
SSH1 |
binds both NOD1 and NOD2 [46] |
actin complexes |
|
regulation of NOD1 signalling [46] |
|
TLE1 |
binds NOD2 [47] |
perinuclear cytosol [47] |
|
inhibits NF-κB signalling [47] |
Crohn's disease [47] |
TRAF4 |
binds NOD1 [48] |
|
|
|
|
binds NOD2 [48] |
|
residues 260–301 [48] |
inhibits NF-κB signalling [48] |
|
TRIM27 |
Does not bind NOD1 [49] |
|
|
|
|
Binds NOD2 [49] |
nucleus [49] |
NACHT [49] |
NOD2 degradation [49] |
|