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Model. CRL4CDT2 substrates are efficiently degraded in early S phase as a result of PCNA loading onto DNA (PCNADNA). Beginning in late S phase, active CDK1 blocks substrate-mediated chromatin recruitment of the CDT2 receptor, allowing reaccumulation of the cohort of CRL4CDT2 substrates that were subject to replication-coupled destruction. Many of these substrates are required for normal mitotic progression.
