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The active site lid shields the substrate and FMN from solvent. A, the two identical polypeptides within the hIYD·I-Tyr structure are indicated by shades of gray. FMN and I-Tyr reside in the active site and are depicted in color. Residues 161–178 of one polypeptide are not shown to reveal the position of FMN and I-Tyr. B, the surface formed by residues 161–178 of the same polypeptide is highlighted in blue to illustrate their ability to cover the active site.
