Figure 1.

Multiple host and environmental factors influence the composition of the microbiome. The schematic illustrates the multiple locations of microbe inhabitance and summarizes the influences of the host and external environment. Systemic stress and exogenous stress molecules have been shown to significantly alter skin barrier permeability function, lipid and antimicrobial peptide (AMP) composition, and wound repair processes.^{9,16–18,20,31,35,63–65} To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound