FIG. 2.

The average pain scores are shown for the primary pain when physically active. The primary pain area was identified for each study participant at baseline, and pain in that area tracked throughout the study. The pain level was scored using Visual Analogue Scales (0–100). The data are shown as mean±SEM. After 2 weeks of consumption, the average pain score was lower in the group consuming oral HMW hyaluronan (HA) than in the placebo group (*P<.065). Analyzing the change in pain reduction within the group consuming oral HMW HA reached a high level of statistical significance at 2 weeks (***P<.001). The mild increase seen between 2 and 4 weeks may be a combination of the lower dose consumed during the second phase and also that people had more physical energy and were more physically active.