Table 1.
Changes in the Levels of Gene Expression in Mouse Livers Between High-Fat Diet and Sesame Oil Diet Groups Were Analyzed by the Global Gene Array
| Gene name | Symbol | ATH/High-fat diet | Seso diet | P value |
|---|---|---|---|---|
| (A) Genes upregulated in cholesterol transport of sesame oil diet-fed animals | ||||
| HDL-associated proteins | ||||
| Apolipoprotein A-I | Apoa1 | 1 | 1.285 | .242 |
| Apolipoprotein D | Apod | 1 | 2.003 | .292 |
| Apolipoprotein F | Apof | 1 | 1.598 | .068 |
| Apolipoprotein L8 | Apol8 | 1 | 1.697 | .110 |
| Cholesterol transporters | ||||
| ATP-binding cassette subfamily A member 1 | Abca1 | 1 | 1.244 | .282 |
| Apolipoprotein A-I | Apoa1 | 1 | 1.285 | .242 |
| Apolipoprotein E | Apoe | 1 | 1.270 | .113 |
| START domain containing 3 | Stard3 | 1 | 1.295 | .126 |
| Cholesterol efflux | ||||
| ATP-binding cassette subfamily A member 1 | Abca1 | 1 | 1.244 | .282 |
| Apolipoprotein E | Apoe | 1 | 1.270 | .113 |
| Reverse cholesterol transport | ||||
| ATP-binding cassette subfamily A member 1 | Abca1 | 1 | 1.244 | .282 |
| Apolipoprotein A-I | Apoa1 | 1 | 1.285 | .242 |
| Apolipoprotein A-II | Apoa2 | 1 | 1.317 | *.041 |
| Apolipoprotein E | Apoe | 1 | 1.270 | .113 |
| Lecithin–cholesterol acyltransferase | Lcat | 1 | 1.225 | .125 |
| Other genes involved in cholesterol transport | ||||
| NPC1-like1 | Npc1l1 | 1 | 1.280 | .567 |
| Oxysterol-binding protein-like 5 | Osbp15 | 1 | 1.605 | .441 |
| (B) Genes upregulated in cholesterol catabolism of sesame oil diet-fed animals | ||||
| Cholesterol catabolism | ||||
| Aldo–Keto reductase family1, member D1 | Akr1d1 | 1 | 1.270 | .318 |
| Apolipoprotein E | Apoe | 1 | 1.270 | .113 |
| Cytochrome P450, family 46, subfamily a, polypeptide 1 | Cyp46a1 | 1 | 1.058 | .926 |
| Cytochrome P450, family 47, subfamily a, polypeptide 1 | Cyp7a1 | 1 | 2.731 | .444 |
| Scavenger receptor class F, member 1 | Scarf1 | 1 | 1.096 | .569 |
| Sorting nexin 17 | Snx 17 | 1 | 1.810 | .422 |
| Cholesterol homeostasis | ||||
| ATP-binding cassette subfamily A member 1 | Abca1 | 1 | 1.244 | .282 |
| Angioprotein-like 3 | Angptl3 | 1 | 1.666 | .130 |
| Apolipoprotein A-I | Apoa1 | 1 | 1.285 | .242 |
| Apolipoprotein A-II | Apoa2 | 1 | 1.317 | *.041 |
| Apolipoprotein E | Apoe | 1 | 1.270 | .113 |
| Lecithin–cholesterol acyltransferase | Lcat | 1 | 1.225 | .125 |
| Low-density lipoprotein receptor | Ldlr | 1 | 1.423 | .360 |
| Ldlr-associated protein 1 | Ldlrap1 | 1 | 1.051 | .588 |
| Proprotein convertase subtilisin/kexin type 9 | Pcsk9 | 1 | 1.064 | .799 |
| Cholesterol biosynthesis | ||||
| Acetyl-Coenzyme A acyltransferase 2 (mitochondrial3-oxoacyl-Coenzyme A thiolase) | Acaa2 | 1 | 1.476 | .059 |
| Cellular nucleic acid-binding protein | Cnbp | 1 | 1.297 | .230 |
| Cytochrome b5 reductase 3 | Cyb5r3 | 1 | 1.537 | *.037 |
| Cytochrome P450, family 51 | Cyp51 | 1 | 1.218 | .212 |
| 24-dehydrocholesterol reductase | Dhcr24 | 1 | 1.212 | .102 |
| Phenylalkylamine Ca+2 antagonist-binding protein | Ebp | 1 | 1.221 | *.014 |
| Farnesyl diphosphate farnesyl transferase 1 | Fdft1 | 1 | 1.419 | *.041 |
| Farnesyl diphosphate synthetase | Fdps | 1 | 1.204 | .712 |
| 3-hydroxy-3-methylgutaryl-Coenzyme A reductase | Hmgcr | 1 | 1.811 | .241 |
| 3-hydroxy-3-methylgutaryl-Coenzyme A synthase 1 | Hmgcs1 | 1 | 1.031 | .778 |
| 3-hydroxy-3-methylgutaryl-Coenzyme A synthase 2 | Hmgcs2 | 1 | 1.235 | .357 |
| Isopenenyl-diphosphate delta isomerase | ldi1 | 1 | 1.287 | .185 |
| Isopenenyl-diphosphate delta isomerase 2 | ldi2 | 1 | 2.988 | .266 |
| Mevalonate decarboxylase | Mvd | 1 | 1.057 | .983 |
| NPC1-like 1 | Npc1l1 | 1 | 1.280 | .567 |
| NAS(P)-dependent steroid dehydrogenase-like | Nsdhl | 1 | 1.936 | .230 |
| Phospho mevalonate kinase | Pmvk | 1 | 1.357 | *.025 |
| Protein kinase, AMP-activated, alpha 2 catalytic subunit | Prkaa1 | 1 | 1.914 | *.031 |
| Transmembrane 7 superfamily member 2 | Tm7sf2 | 1 | 1.519 | .295 |
| Other genes involved in cholesterol metabolism | ||||
| ATP-binding cassette subfamily A member 2 | Abca2 | 1 | 1.036 | .762 |
| Apolipoprotein B | Apob | 1 | 1.053 | .990 |
| Apolipoprotein c3 | Apoc3 | 1 | 1.568 | *.014 |
| Apolipoprotein f | Apof | 1 | 1.598 | .068 |
| Apolipoprotein L8 | Apol8 | 1 | 1.697 | .110 |
| Cytochrome P450, family 7, subfamily b polypeptide 1 | Cyp7b1 | 1 | 2.731 | .444 |
| Chymotrypsin-like elastase family, member 3B | Cela3b | 1 | 1.774 | .525 |
| High-density lipoprotein (HDL)-binding protein | Hdlbp | 1 | 1.041 | .577 |
| Interleukin 4 | Il4 | 1 | 1.674 | .322 |
| Leptin | Lep | 1 | 1.529 | .315 |
| Lipase, hormone sensitive | Lipe | 1 | 1.008 | .966 |
| Membrane-bound transcription factor peptidase, site1 | Mbtps1 | 1 | 1.702 | .354 |
| Nuclear receptor subfamily o, group B, member 2 | Nrob2 | 1 | 1.157 | .597 |
| Nuclear receptor subfamily1, group H, member 4 | Nr1h4 | 1 | 1.728 | *.041 |
| Oxysterol-binding protein-like 1A | Osbpl1a | 1 | 1.181 | .300 |
| Oxysterol-binding protein-like 5 | Osbpl5 | 1 | 1.605 | .441 |
| SRBEF Chaperone | Scap | 1 | 1.293 | *.024 |
| Sterol O-acyl transferase2 | Soat2 | 1 | 1.105 | .418 |
| Sterol regulatory element-binding transcription factor 1 | Srebf1 | 1 | 1.020 | .962 |
| START domain containing 3 | Stard3 | 1 | 1.295 | .126 |
| Very low-density lipoprotein receptor | Vldlr | 1 | 1.180 | .594 |
The results are expressed as fold change between the groups. *P<0.05.