TABLE 1 .
Collected clonal C. trachomatis strains and their KSK120 susceptibility
| Strains with indicated substitution(s)a | Fold increase in infectious EBsb | Mutant passage (P), parental strain |
|---|---|---|
| Wild type | 1 (±0.38) | Wild-type population |
| UhpCL429I | 18.7 (±1.33) | Wild-type population |
| UhpCL429I, M315I | 141 (±19.2) | P9, wild-type population |
| UhpCA394T | 205 (±42.65) | P10, clonal wild type |
| PgiH378P | 74.44 (±17) | P10, clonal wild type |
| RecCM415I | 118 (±20.1) | P10, clonal wild type |
| EF-PR131C | 186.83 (±19.61) | P9, wild-type population |
| UhpCL429I, M315I, RpoCC1224F | 242.52 (±30.38) | P15, wild-type population |
| UhpCL429I, M315I, RpoCC1224F, EF-PR131C | 169.86 (±23.76) | P15, wild-type population |
a
Isolated by plaque purification, lacking the other identified mutations.
b
Infectious EB progeny generated (at 44 hpi) in the presence of 10 µM KSK120, normalized to input inclusion-forming units (IFU). The values for the wild type were set to 1. Representative data are from an experiment performed in triplicate ± SD.