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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Toxicol Environ Health A. 2015;78(1):15–31. doi: 10.1080/15287394.2015.958417

Figure 5. Time-course analysis of TCE metabolism in C57BL/6J and NZW/LacJ mice in a sub-chronic study.

Figure 5

Serum (A) and liver (B) levels of metabolites were assessed 2 h following the last dose after 1, 2 or 4 wks (100 or 400 mg/kg/d) of TCE. Box and whiskers plots are shown (+, mean; line, median; box, inter-quartile range; whiskers, min to max). Light-gray, 100 mg/kg/d groups; dark gray, 400 mg/kg/d groups. When box is shown, 4 animals per group were available. Otherwise, there were 3 animals per group. Asterisks denote a significant (p<0.05) difference as compared to (*) the group dosed with 100 mg/kg/d (same strain and time point), (#) the 5 day treatment group (same strain and dose), or (&) the values in C57BL/6J strain (same dose and time point).