Figure 1.

MicroRNA-mediated metabolism. The figure shows aspects of microRNA-mediated glucose and glutamine metabolism in cancer. Black arrows show the catabolic and anabolic processing of metabolites. The larger black arrows represent pathways that are upregulated in HCC, and the broken arrows signify that metabolic intermediates are not shown. MicroRNAs in blue are downregulated in HCC, and those in orange are upregulated. MicroRNA-mediated regulations are shown in red for inhibition and green for activation. The broken arrows represent mechanisms in which the microRNA does not directly target an enzyme within the specified metabolic pathway. The question marks next to some of the miR-155 regulations indicate mechanisms that are yet to be elucidated. GLUT, glucose transporter; MCT4, monocarboxylate transporter 4; G6PD, glucose-6-phosphate dehydrogenase; TKT, transketolase.