. 2014 Summer;5(3):97–107.

Table 1. Evidence table summary of different laser used in Removal of oral mucosa lesions .

Study type	Author	year	Sample size	Laser type	Laser parameters	Result
Randomized clinical trial	Lopez-jornet²⁰	2013	48	CO₂ laser		The CO₂ laser causes only minimal pain and swelling
Randomized clinical trial	Simsek¹⁵	2012	20	-gallium aluminum arsenide diode laser -Er:YAG laser	- continuous wavelength of 808 nm, -continuous wavelength of 2,940 nm	Diode and Er:YAG lasers administered at 1 W both result in satisfactory depigmentation
Randomized clinical trial	Agha-Hosseini¹¹	2012	57	low-level laser CO(2) laser		Both methods may be effective in the treatment of OLP
Clinical trial	Kawczyk ⁶	2012	85	photodynamic therapy (δ-aminolevulinic acid (ALA)	630-635 nm wavelength	PDT is more convenient for patients, less painful, and more esthetic.
Prospective study	Montebugnoli⁸	2012	13	Nd:YAG laser		clinical healing of leukoplakia treated by laser surgery may be accompanied by altered cell turnover in 20% of the cases
Prospective study	Jerjes¹⁷	2012	123	CO(2) laser		Laser resection/ablation is recommended for oral dysplasia to prevent recurrence and malignant transformation
Prospective study	Deppe¹⁸	2012	148	CO(2) laser		CO(2) laser was used in treatment of premalignant lesions of the oral mucosa
Retrospective study	Luna-oritz ¹⁹	2011	4	CO(2) laser		CO₂ laser is adequate for melanomas of the oral mucosa with extraction of the dental organs
Clinical study	Hegde ¹³	2013	140	CO₂ laser Er:YAG laser	(CO₂ laser, 2 to 4 W, continuous wave),and "brushstroke" (Er:YAG laser, 180 mJ, 10 Hz, long pulse)	Surgical stripping for gingival depigmentation remains the gold standard; however, Er:YAG laser and CO₂ lasers can be effectively used but with distinct differences.
Clinical study	Fornaini²¹	2012	52	KTP laser	the KTP laser (532 nm), used with low power parameter (1 Watt - CW)	KTP laser with low parameters permits to perform oral surgery with good pain control and good wound healing
Clinical study	Yang‏ ⁹	2011	114	CO(2) laser		Continuous smoking after surgical treatment and widespread multiple-focus lesions are the prognostic indicators for recurrence after laser surgery.
Case report	Misra¹⁰	2013	1	Diode laser	diode laser (940 nm)	Diode laser therapy seems to be an effective alternative treatment for relieving the symptoms of OLP
Case report	Fornaini ¹²	2012	2	Er: YAG laser	energy, 80-120 mJ; frequency, 6-15 Hz; non-contact hand piece; spot size diameter, 0.9 mm; pulse duration, 100 μsec (VSP) to 300 μsec (SP) ; fluences, 12.6-18.9 J/cm(2); and air/water spray (ratio: 6/5)	The use of this wavelength offers several advantages including, a good and fast healing process, a very low level of discomfort during and after intervention, and a rapid disappearance of symptoms.
Case report	de Magalhaes-Junior¹³	2011	1	CO₂ laser		The use of the CO₂ laser was found to be useful and effective to treat lichen planus.
Non-randomized single arm, single site	Shafirstein ⁷	2011	23	Pulsed dye laser		It could be used to achieve regression of oral leukoplakia