Table 1. Evidence table summary of different laser used in Removal of oral mucosa lesions .

Study type	Author	year	Sample size	Laser type	Laser parameters	Result
Randomized clinical trial	Lopez-jornet20	2013	48	CO₂ laser		The CO₂ laser causes only minimal pain and swelling
Randomized clinical trial	Simsek15	2012	20	-gallium aluminum arsenide diode laser -Er:YAG laser	- continuous wavelength of 808 nm, -continuous wavelength of 2,940 nm	Diode and Er:YAG lasers administered at 1 W both result in satisfactory depigmentation
Randomized clinical trial	Agha-Hosseini11	2012	57	low-level laser CO(2) laser		Both methods may be effective in the treatment of OLP
Clinical trial	Kawczyk 6	2012	85	photodynamic therapy (δ-aminolevulinic acid (ALA)	630-635 nm wavelength	PDT is more convenient for patients, less painful, and more esthetic.
Prospective study	Montebugnoli8	2012	13	Nd:YAG laser		clinical healing of leukoplakia treated by laser surgery may be accompanied by altered cell turnover in 20% of the cases
Prospective study	Jerjes17	2012	123	CO(2) laser		Laser resection/ablation is recommended for oral dysplasia to prevent recurrence and malignant transformation
Prospective study	Deppe18	2012	148	CO(2) laser		CO(2) laser  was used in treatment of premalignant lesions of the oral mucosa
Retrospective study	Luna-oritz 19	2011	4	CO(2) laser		CO2 laser is adequate for melanomas of the oral mucosa with extraction of the dental organs
Clinical study	Hegde 13	2013	140	CO2 laser   Er:YAG laser	(CO2 laser, 2 to 4 W, continuous wave),and "brushstroke" (Er:YAG laser, 180 mJ, 10 Hz, long pulse)	Surgical stripping for gingival depigmentation remains the gold standard; however, Er:YAG laser and CO2 lasers can be effectively used but with distinct differences.
Clinical study	Fornaini21	2012	52	KTP laser	the KTP laser (532 nm), used with low power parameter (1 Watt - CW)	KTP laser with low parameters permits to perform oral surgery with good pain control and good wound healing
Clinical study	Yang‏ 9	2011	114	CO(2) laser		Continuous smoking after surgical treatment and widespread multiple-focus lesions are the prognostic indicators for recurrence after laser surgery.
Case report	Misra10	2013	1	Diode laser	diode laser (940 nm)	Diode laser therapy seems to be an effective alternative treatment for relieving the symptoms of OLP
Case report	Fornaini 12	2012	2	Er: YAG laser	energy, 80-120 mJ; frequency, 6-15 Hz; non-contact hand piece; spot size diameter, 0.9 mm; pulse duration, 100 μsec (VSP) to 300 μsec (SP) ; fluences, 12.6-18.9 J/cm(2); and air/water spray (ratio: 6/5)	The use of this wavelength offers several advantages including, a good and fast healing process, a very low level of discomfort during and after intervention, and a rapid disappearance of symptoms.
Case report	de Magalhaes-Junior13	2011	1	CO2 laser		The use of the CO2 laser was found to be useful and effective to treat lichen planus.
Non-randomized single arm, single site	Shafirstein 7	2011	23	Pulsed dye laser		It could be used to achieve regression of oral leukoplakia