Table 2. Evaluation of DIAGNOdent in primary caries of deciduous teeth .

	First author’s Name/year	In vitro\ In vivo	Sample volume	Occlusal/ Proximal	Comparison of Methods	Gold Standard	Results	Conclusion
1	J. F. Souza 201232	In vitro	79 Human molars	Occlusal	1. Visual method (ICDAS II) 2. Radiography BW 3. DIAGNOdent (LF) 2095 4. DIAGNOdent (LF Pen) 2190 5. Fluorescence camera VistaProof (FC)	Histology	ICDAS and FC showed better accuracy in detection of enamel and dentin caries lesions. While ICDAS, LF, LF Pen and FC had no significant statistical difference in the diagnosis of lesions in occlusal surfaces of deciduous teeth, attention has to paid to this important point that new methods such as methods based on fluorescence should be considered as complementary methods in the detection of caries	=*
2	Neuhaus K W 201133	In vitro	37 Human molars	Occlusal	1. DIAGNOdent (Pen) 2. DIAGNOdent (LF) 2095 3. Radiography (BW) 4. Visual Method (ICDAS)	Histology	After primary visual examination with ICDAS or without it, use of LF Pen could be helpful in the diagnosis of deciduous occlusal caries. Bitewing radiography could only show proximal caries	=
3	DeBenedetto MS 201118	In vitro	129 Human molars Occlusal regions (96) Smooth regions (113)	Occlusal and Smooth regions	1. DIAGNOdent (LF) 4. DIAGNOdent (LF Pen) 5. Fluorescence camera (FC) Vistaproof	-	In general when FC is used on occlusal and smooth surfaces, it has a higher efficiency, just like any other device operating with fluorescent light	=
4	Celiberta P 201034	In vitro	123 Human molars	Proximal	1. Visual method 2. DIAGNOdent (Pen)	Histology	LF is not able to evaluate and the depth of proximal caries and shows that it is not reliable in deciduous molar teeth. Therefore the result is that this method is not suitable to detect proximal caries in deciduous molars and especially in regions not cu.	-**
5	Goel A 200935	In vivo	84 first and second molars	Occlusal	1. DIAGNOdent (LF) 2. Radiography (BW) 3. Visual method 4. Tactile	Histology	DIAGNOdent showed that it has superior sensitivity and accuracy in diagnosis of dentinal caries compared to other usual methods. Although DIAGNOdent had a high sensitivity for dentinal caries detection, but it was similar to other caries diagnostic methods.	+***
6	Braga MM 200936	In vitro	131 Human molars	Proximal	1. Visual method (ICDAS II) 2. Radiograhy (BW) 3. DIAGNOdent (Pen)	Histology	Visual method has showed better results in these in vitro studies for diagnosis of proximal caries in deciduous teeth. Even though both methods Radiography and LF Pen had a good efficiency particularly in detecting advanced caries	-
7	Kavvadia K 200837	In vivo	405 Human molars	Occlusal	1. Direct visual method (DV) 2. Indirect visual method (IDV) 3. Radiography BW 4. DIAGNOdent (LF)	Fissure opening	DIAGNOdent is very reliable in detection of occlusal caries in deciduous teeth and its efficiency is similar to direct visual method and radiography	=
8	Virajsilp V 200538	In vitro	107 Human molars	Proximal	1. DIAGNOdent (LF) 2. Radiography (BW)	Histology	DIAGNOdent is very reliable and the validity of its diagnostic (sensitivity and specificity) was higher than radiography bitewing in the detection of proximal caries in deciduous teeth	+
9	Anttonen V 200429	In vivo	423 Human permanent molars 315 Human deciduous molars	Occlusal	1. Visual method 2. DIAGNOdent (LF)	-	Results showed that DIAGNOdent in combination to visual method is beneficial tool for dentists with less experience for the diagnosis of caries in deciduous and permanent molar teeth.	=
10	Attrill DC 200139	In vitro	58 Human molars	Occlusal	1. DIAGNOdent (LF) 2. Radiography 3. Visual method	Histology	DIAGNOdent is the more accurate evaluation system for the detection of occlusal surfaces dentinal caries in deciduous molars. The efficiency of DIAGNOdent in terms of statistics was not significant compared to visual method in teeth without cavity preparation. DIAGNOdent can be considered as a beneficial clinical tool, although with proper training visual method could have similar results without any needs for additional equipment	=

* Meaning of = is that DIAGNOdent has no significant difference in comparison to other methods for detection of caries

** Meaning of – is that other methods have better results compared to DIAGNOdent for diagnosis of caries

*** Meaning of + is that DIAGNOdent has a better results compared to other methods for diagnosis of caries