Table 3. Evaluation of DIAGNOdent in secondary carie in permanent teeth .

	First author’s Name/year	In vitro\ In vivo	Sample volume	Occlusal/ Proximal	Comparison of Methods	Gold Standard	Results	Conclusion
1	K. W. Neuhaus 201233	In vitro	75 Human molars	Proximal	1. DIAGNOdent (LF) 2. Radiography BW	Histology	Results showed that use of LF in comparison with BW for proximal in the cervical region of margins of amalgam restorations led to better detection of secondary caries which had not extended to CEJ	+*
2	Kositbowornchai S 201240	In vitro	100 Human molars	Occlusal	. 1.DIAGNOdent (LF) 2. Radiography Digital	Histology	Use of Diagnodent in comparison to digital radiography in the diagnosis of caries under posterior composite restorations had no significant difference	=**
3	Rodrigues JA 201041	In vitro	43 Human molars (60 regions)	Proximal	1. Visual method (VE) 2. Radiography (BW) 3. Visual method and radiography (VEBW) 4. DIAGNOdent (Pen)	Histology and hardness measuring	DIAGNOdent has to be considered as a complementary method in the diagnosis of secondary proximal caries in relation to composite restorations	=
4	Bamzahim M 200542	In vivo	51 Human premolars and molars	Occlusal and Proximal	1. DIAGNOdent (LF) 2. Radiography BW 3. Visual method	Visual and Tactile	Results of this study showed that treatment decision shouldn’t be made of the basis of DIAGNOdent findings alone. Even if this device could be used as a valuable complementary tool for usual methods in the diagnosis of secondary caries of teeth restored with amalgam.	=
5	Ando M 200410	In vitro	50 Human premolar and molars	Occlusal and Proximal	1. DIAGNOdent (LF) 2. Visual method	CLSM (confocal laser scanning microscopy	Results obtained from this study suggest that LF and QLF could improve the ability to diagnose secondary caries around amalgam restorations	+
6	Bamzahim M 200412	In vitro	66 Teeth	Occlusal	1. DIAGNOdent (LF) 2. Radiography Digital (BW)	Histology	Results showed that DIAGNOdent could be a beneficial tool in the detection of secondary caries	=
7	Boston DW 200343	In vitro	15 Teeth (30 regions)	-	1. DIAGNOdent (LF) 2. Visual method	Histology	DIAGNOdent is better than visual method in the diagnosis of secondary caries of dentin compared to visual method, but with no significant difference	=

* Meaning of + is that DIAGNOdent has a better results compared to other methods for diagnosis of caries

** Meaning of = is that DIAGNOdent has no significant difference in comparison to other methods for detection of caries