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. 2014 Mar 29;166(1):98–108. doi: 10.1111/bjh.12854

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© 2014 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 3 — Kaplan-Meier's estimate of overall survival and event-free survival in relation to MIPI, MIPI-B, SOX11/MIPI and TP53/MIPI. (A) OS and (B) EFS analysis using the Kaplan-Meier method reveal a poor separation between MIPI^low and MIPI^intermediate groups. When applying the proposed biological MIPI (MIPI-B) both (C) OS and (D) EFS analysis show inverted low and intermediate survival curves. The combined SOX11/MIPI improves separation between low and intermediate risk groups (although, P > 0·05) in relation to (E) OS and (F) EFS. The combined TP53/MIPI show significant (P = 0·006) separation between low and intermediate risk groups in relation to (G) OS and identifies a high risk group with decreased (H) EFS. OS, overall survival; EFS, event-free survival; MIPI, Mantle cell lymphoma International Prognostic Index; MIPI-B, biological MIPI.