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Hypothetical mechanism of cadherin and nectin cluster assembly. (A) Actin filaments are disorganized in the actin cortex. (B) Filaments are specifically aligned owing to the adhesive clustering of the cadherin–catenin complex. (C) The resulting cadherin-associated actin filament structure becomes the substrate for nectin–afadin clustering. Nectin–afadin clusters could reinforce the actin structure and facilitate further clustering of cadherin.
