Table 2.
Summary of sensitivity analyses
| Overall analysis | Sensitivity analysis | |||||
|---|---|---|---|---|---|---|
| Effect size | P | Excluded study | Effect size | P | ||
| Reference | Weight (%) | |||||
| Clinical endpoints | ||||||
| Acute kidney injury | RR 1·64 (1·27, 2·13) | < 0·001 | Yunos et al.26 | 77·0 | RR 1·65 (0·95, 2·87) | 0·078 |
| Hyperchloraemia/metabolic acidosis | RR 2·87 (1·95, 4·21) | < 0·001 | Zunini et al.56 | 65·5 | RR 8·50 (2·49, 29·08) | 0·001 |
| Mortality | RR 1·13 (0·92, 1·39) | 0·230 | Yunos et al.26 | 65·0 | RR 1·17 (0·81, 1·68) | 0·401 |
| ICU LOS | SMD −0·01 (−0·10, 0·09) | 0·897 | Yunos et al.26 | 88·7 | SMD −0·07 (−0·35, 0·21) | 0·624 |
| Hospital LOS | SMD −0·07 (−0·13, −0·01) | 0·017 | Shaw et al.27 | 60·1 | SMD −0·01 (−0·10, 0·08) | 0·849 |
| Surrogate endpoints | ||||||
| Serum chloride | MD 3·70 (3·36, 4·04) | < 0·001 | Yunos et al.55 | 55·3 | MD 5·31 (4·79, 5·82) | < 0·001 |
| Mechanical ventilation time | SMD 0·15 (0·08, 0·23) | < 0·001 | Shaw et al.27 | 95·1 | SMD −0·06 (−0·38, 0·27) | 0·734 |
Values in parentheses are 95 per cent c.i. RR, risk ratio; ICU, intensive care unit; LOS, length of stay; SMD, standardized mean difference; MD, mean difference.