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Selective CDK4/6 inhibition by small molecule compound. (A) Schematic diagram of the cell cycle and function of a selective CDK4/6 specific inhibitor. E2F, E2 transcription factor; DP, E2F dimerization partner; R, restriction checkpoint. (B) Whole cell extracts with or without CCI treatment were assayed for protein levels of phospho-Rb (p-Rb), phospho-ERK (p-ERK), phospho-S6 (p-S6) by Western blot. Rab11 was used as a loading control.
