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The effects of CKD4/6 inhibitor treatment in CHO recombinant cell production cultures. A recombinant CHO cell line was subjected to a 5-day 24DWP production assay, using batch medium with or without the indicated amount of inhibitor. VCD (A), viability (B), qP (C), HMW (D), and high mannose (E) were measured daily as described in the Materials and Methods section. Data represent the average ± SD of three biological replicates.
