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. 2014 Apr 22;56(4):614–630. doi: 10.1002/bimj.201300153

Table 1.

Maximum type 1 error rate for Inline graphic with and without treatment selection, with or without adjustment for multiplicity and with equal or flexible second-to-first stage ratios as compared to the case Inline graphic

nominal α Inline graphic Inline graphic
Inline graphic Inline graphic Inline graphic
treatment selection of most promising treatment
equal (Proschan and Hunsberger, 1995) flexible (Graf and Bauer, 2011) equal (Section 4.1) flexible (Section 4.2) equal (Section 4.1) flexible (Section 4.2)
0.01 0.0267 0.0491 0.0398 0.0697 0.0224 0.0407
0.025 0.0616 0.1064 0.0887 0.1466 0.0518 0.0892
0.05 0.1146 0.1867 0.1594 0.2496 0.0968 0.1588
without treatment selection
equal (Proschan and Hunsberger, 1995) flexible (Graf and Bauer, 2011) equal (Section 5.1) flexible (Section 5.2) equal (Section 5.1) flexible (Section 5.2)
0.01 0.0267 0.0491 0.0478 0.0800 0.0263 0.0473
0.025 0.0616 0.1064 0.1058 0.1701 0.0610 0.1037
0.05 0.1146 0.1867 0.1897 0.2885 0.1138 0.1842