Table 2.

Dosimetry, toxicity, local control and survival rates of brain metastases patients treated with VMAT

Source	Conformity index (CI)	Toxicity	Local control/overall survival
Awad et al.14	Mean CI = 8.6a	‐Minimal acute toxicity: ‐Alopecia, headache, vomiting ‐Grade I toxicity‐ 5 patients ‐Grade I/II toxicity‐ 2 patients ‐Grade II toxicity‐ 3 patients ‐Grade IV late toxicity‐ 1 patient	‐Mean survival = 9.4 months ‐81% of lesions controlled 3.5 months post‐radiotherapy
Hsu et al.2	Mean CI = 0.73 ± 0.10	N/A	N/A
Huang10	Mean CI = 1.43 ± 0.3	N/A	N/A
Lagerwaard et al.12	Mean CI = 1.3 ± 0.3	N/A	N/A
Lee et al.1	N/A	‐Grade I pruritus in 1 patient ‐No toxicity of grade 3 or above was found during or after treatment.	Survival at: ‐6 months = 66.7% ‐12 months = 41.7% ‐Mean OS= 9 months ‐Mean local progression‐free survival = not achieved
Wang et al.13	Mean CI = 1.6 ± 0.4	‐Grade I/II alopecia in 31% of patients	N/A
Weber et al.3	N/A	‐Alopecia observed in less than a third of the patients	‐6 months OS = 72% in patients who underwent prior surgical resection ‐6 months OS = 66.9% in patients with good performance status ‐79% local and distant control achieved

N/A, not available in these studies; OS, overall survival.

^aThere was a high percentage of major deviations within this study due to the GTV volumes measuring <1 cm³.