Table 2.
Smoking cessation outcome
| Outcome measure | NRT | Bupropion | Combination | Odds ratio bupropion versus NRT (95% CI) | Odds ratio combination versus pooled NRT and bupropion (95% CI) |
|---|---|---|---|---|---|
| ITT samplea | (n = 418) | (n = 409) | (n = 244) | ||
| Primary outcome (RS6) % (n) | 24.2 (101) | 26.7 (109) | 23.4 (57) | 1.14 (0.834–1.56) | 0.896 (0.640–1.25) |
| Secondary outcome (DH4) % (n) | 58.9 (246) | 53.8 (220) | 54.5 (133) | 0.814 (0.618–1.07) | 0.928 (0.697–1.24) |
| Secondary outcome (PP6) % (n) | 28.2 (118) | 32.3 (132) | 27.5 (67) | 1.21 (0.900–1.63) | 0.874 (0.636–1.20) |
| Treated sampleb | (n = 418) | (n = 373) | (n = 223) | ||
| Primary outcome (RS6) % (n) | 24.2 (101) | 27.9 (104) | 24.2 (54) | 1.21 (0.883–1.67) | 0.913 (0.647–1.29) |
| Secondary outcome (DH4) % (n) | 58.9 (246) | 54.4 (203) | 55.6 (124) | 0.835 (0.63–1.11) | 0.954 (0.707–1.29) |
| Secondary outcome (PP6) % (n) | 28.2 (118) | 33.8 (126) | 28.7 (64) | 1.30 (0.959–1.76) | 0.902 (0.651–1.25) |
RS6 = Russell Standard sustained 6-month carbon monoxide (CO)-verified cessation; DH4 = Department of Health weeks 3 and 4 post-quit day CO-verified cessation; PP6 = 7-day CO-verified point prevalence at 6 months.
a
Intention-to-treat (ITT)—sample as randomized.
b
Treated sample—excluding 57 participants known not to have received bupropion. CI = confidence interval; NRT = nicotine replacement therapy.