Table 4.
Association between PPARγ2 CG/GG genotype (Ala variant) and serum adipokines in HIV/HCV coinfected patients
| CC | CG/GG | p-value (a) | aAMR (95% CI) | p-value (b) | |
|---|---|---|---|---|---|
| HGF (pg/mL) | 1964.9 (2079.2) | 1044.4 (1327.1) | 0.003 | 0.61 (0.39; 0.94) | 0.028 |
| NGF (pg/mL) | 9.48 (9.43) | 6.16 (8.32) | 0.008 | 0.47 (0.26; 0.84) | 0.010 |
| PAI-1 (pg/mL) | 1474.9 (17338.2) | 1363.1 (7366.9) | 0.721 | 0.783(0.36; 1.69) | 0.534 |
| Leptin (pg/mL) | 3438.1 (154050.1) | 5547.6 (22928.2) | 0.529 | 0.93 (0.55; 1.58) | 0.795 |
| Resistin (pg/mL) | 1233.1 (15063.9) | 1070.4 (2795.7) | 0.478 | 0.76 (0.39; 1.47) | 0.425 |
| Adiponectin (ng/mL) | 662.9 (10917.3) | 1226.6 (4993.1) | 0.634 | 1.14 (0.39; 3.31) | 0.800 |
Values expressed as median [interquartile range = upper quartile (Q3) - lower quartile (Q1)] and adjusted arithmetic mean ratio (aAMR) [95% of confidence interval (95% CI)]. Statistically significant differences are shown in bold. (a)P-values were calculated by generalized linear models (GLM) with gamma distribution (log-link). (b)P-values were calculated by GLM with log-link adjusted by the most important clinical and epidemiological characteristics (see Statistical analysis section).
Abbreviations: HCV hepatitis C virus, HIV human immunodeficiency virus, HGF hepatic growth factor, NGF nerve growth factor, PAI-1 plasminogen activator inhibitor-1.