Table 5.

Bleeding Definitions

PLATO definition30		TIMI definition62
Major bleeding	Fatal bleeding Intracranial hemorrhage Clinically overt or apparent bleeding with a drop in Hgb ≥ 3 g/dl Transfusion of ≥ 2 units of whole blood or PRBCs Severe hypotension requiring pressors or surgery; intrapericardial hemorrhage with tamponade; hypovolemic shock Substantially disabling	Major bleeding	Fatal bleeding Leads to hypotension and requires i.v. inotropic agents Requires surgical intervention Transfusion of ≥ 4 units of whole blood or PRBCs Intracranial hemorrhage Clinically overt with a drop in Hgb > 5 g/dl or drop in HCT > 15%
Minor bleeding	Requires medical intervention to stop or treat bleeding	Minor bleeding	Clinically overt with a drop in Hgb of 3 to ≤ 5 g/dl or drop of HCT of 9 to ≤ 15%
Minimal bleeding	All other bleeding not requiring intervention	Minimal bleeding	Clinically overt with drop in Hgb < 3 g/dl or drop in HCT < 9%

HCT = hematocrit; Hgb = hemoglobin; i.v. = intravenous; PLATO = Platelet Inhibition and Patient Outcomes; PRBCs = packed red blood cells; TIMI = Thrombolysis in Myocardial Infarction.