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(A) Change from baseline in frequency of spontaneous bowel movements (SBMs) in patients treated with lubiprostone 24 mcg twice daily compared with placebo (intent-to-treat population). P values from van Elteren tests stratified by pooled center. (B) Percentage of patients with first SBM within 24 and 48 hours of initial dose of lubiprostone 24 mcg twice daily compared with placebo. P values are from χ2 tests. No imputation of missing data was performed.
