. 2014 Feb 13;10(4):481–495. doi: 10.1111/mcn.12110

Table 1.

Overview of multi‐year studies in rats with high levels of oral intake of EDTA

Reference	EDTA		Highest dosage level
Reference	Chemical form	Molecular mass (in mg mmol⁻¹)	In the feed	As mg day⁻¹ kgbw⁻¹ *	As μmol day⁻¹ kgbw⁻¹
BIBRA 1964, ^†	Na₂H₂EDTA	336	5%	2500	7440
BIBRA 1964, ^†	Na₂H₂EDTA	336	1%	500	1488
Oser et al. 1963	CaNa₂EDTA	374	5000 ppm	250	668
NCI 1977	EDTA‐Na₃H·3H₂O	412	7500 ppm	375	912

*A conversion factor of 20 was used for concentration in the feed and the intake per day per kilogram bodyweight (Oser et al. 1963). ^†For the 1952 Yang study (BIBRA 1964), the second highest dosage level has also been included.