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. 2014 Sep 5;33(21):2521–2533. doi: 10.15252/embj.201488663

Figure 7. Model for G4 DNA recognition and unwinding during DNA replication.

Figure 7

(A) When the DNA replication machinery encounters a G-quadruplex structure, it temporarily stalls right at the G4 site (G4 detection). Stable G-quadruplex structures depend on FANCJ for their resolving (B), while others are resolved through FANCJ-independent mechanisms (D) after which DNA synthesis proceeds and the G4 sequence is faithfully replicated. In the absence of FANCJ (C), the G-quadruplex structures are not resolved leading to persistent replication stalling at the G4 sequence.