Table 3.

Signal Decay Parameters Estimated from the Averaged Simulated DW Images at Different Applied Noise Levels σ_applied Using the MP, MD, and NR Algorithms (simulation 2)^a

	Metastatic tissue
	DME	Dfast	DSE	α	DBE	f	D*BE
TRUE	1.31	3.49	0.98	0.45	0.59	0.33	17.48
	SNR = 3
NR	0.91	2.54	0.38	0.39	0.33	0.38	6.58
MP	1.24	3.48	0.66	0.43	0.49	0.35	10.99
MD	1.37	3.49	0.60	0.42	0.42	0.37	10.68
	SNR = 5
NR	1.18	3.23	0.8	0.43	0.44	0.37	10.13
MP	1.3	3.51	0.96	0.45	0.56	0.34	13.59
MD	1.29	3.51	0.96	0.45	0.55	0.34	13.73
	SNR = 8
NR	1.26	3.47	0.93	0.46	0.51	0.35	14.35
MP	1.3	3.47	0.95	0.46	0.59	0.33	16.39
MD	1.28	3.47	0.96	0.48	0.57	0.34	15.83

^aThe applied noise levels corresponding to SNR = 3, 5, and 8 of the b = 1000 s/mm² DW image. The estimated decay parameters were compared with the ground truth decay parameters (true) derived from noise-free averaged DW images with the NR algorithm. Comparison includes the ROI corresponding to the metastatic tissue. Diffusion coefficients (abbreviations shown in Table1 are given in units of 10⁻³ mm²/s.