Table 2.
Subjects' characteristics at OL baseline (all treated subjects)
| Early PD | Advanced PD | ||
|---|---|---|---|
| Duration of preceding study | 33 weeks | 11–13 weeksa | Up to 33 weeks |
| N in OL extension | 368 | 143 | 391 |
| Sex, n (% of group) | |||
| Males | 204 (55.4) | 81 (56.6) | 213 (54.5) |
| Females | 164 (44.6) | 62 (43.4) | 178 (45.5) |
| Age (years), mean (SD) | 62.2 (9.2) | 64.0 (9.0) | 61.6 (9.7) |
| Race, n (% of group) | |||
| White | 222 (60.3) | 139 (97.2) | 192 (49.1) |
| Asian | 146 (39.7) | 4 (2.8) | 199 (50.9) |
| PD duration (years), mean (SD) | 1.6 (1.1) | 3.6 (2.1) | 7.0 (4.2) |
| Hoehn and Yahr stage, n (% of group)b | |||
| 1–1.5 | 147 (39.9) | 59 (41.3) | 2 (0.5) |
| 2–3 | 221 (60.1) | 84 (58.7) | 351 (89.8) |
| 4–5 | 0 (0.0) | 0 (0.0) | 37 (9.5) |
| Missing | 0 (0.0) | 0 (0.0) | 1 (0.3) |
| UPDRS score, mean (SD) | |||
| Part IIc | 5.2 (3.7) | 6.8 (3.7) | 8.8 (6.0)d |
| Part III | 13.8 (8.5) | 14.6 (8.2) | 19.7 (12.3) |
| Parts II+III | 19.0 (11.6) | 21.4 (11.0) | 28.6 (17.4)d |
| ‘Off’ time, mean (SD) | |||
| % of waking day | – | – | 23.6 (17.0)e |
| Hours/day | – | – | 3.7 (2.8)e |
OL, open-label; PD, Parkinson's disease; SD, standard deviation; UPDRS, Unified Parkinson's Disease Rating Scale.
a
Not including IR pre-treatment for ≥3 months
b
in advanced PD, assessed during ‘on’ time
c
in advanced PD, ‘on’ time/‘off ’ time average
d
n = 389
e
n = 386.