Table 1.

Summary of On-Therapy Adverse Effects Occurring in Two or More Subjects, No. (%)

Preferred term	Placebo	ETOH, 0.5 g/kg	GSK152149,8 20 mg	GSK1521498 + ETOH at 1 hour	GSK1521498 + ETOH at 4 hours
Total subjects	26	25	23	4	23
Any adverse event	4 (15)	11 (44)	5 (22)	4 (100)	7 (30)
Nausea	1 (4)	1 (4)	2 (9)	1 (25)	3 (13)
Dizziness	0	4 (16)	0	0	2 (9)
Fatigue	1 (4)	0	2 (9)	0	2 (9)
Headache	1 (4)	0	1 (4)	0	3 (13)
Vomiting	1 (4)	0	1 (4)	1 (25)	1 (4)
Tandem gait test abnormal	0	2 (8)	0	0	2 (9)
Gait disturbance	0	1 (4)	0	2 (50)	0
Coordination abnormal	0	1 (4)	0	1 (25)	1 (4)
Positive Rombergism	0	2 (8)	0	0	1(4)
Feeling drunk	0	1 (4)	0	0	1 (4)
Abdominal distension	0	0	1 (4)	0	1 (4)
Somnolence	0	0	0	1 (25)	1 (4)
Disturbance in attention	0	0	0	0	2 (9)
Skin irritation	1 (4)	0	1 (4)	0	0
Euphoric mood	0	1 (4)	1 (4)	0	0
Decreased appetite	0	0	1 (4)	0	1 (4)