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. 2014 May 9;30(11):1085–1102. doi: 10.1002/cnm.2645

Table II.

Definitions of the π functions used in the concentration equations in Table1.

PTH stimulates the production of RANKL Inline graphic
PTH inhibits the production of OPG Inline graphic
IL-6 stimulates the production of RANKL Inline graphic
VAL-4 stimulates the production of IL-6 Inline graphic
TGF − β stimulates the production of IL-6 Inline graphic
SLRPs produced by mature osteoblasts suppresses the proliferation of MM cells Inline graphic

RANKL, receptor activator of nuclear factor kappa-B ligand; OPG, osteoprotegerin; TGF-β, transforming growth factor-beta; PTH, parathyroid hormone; IL-6, interleukin-6; SLRP, small leucine-rich proteoglycan; VLA-4, very late antigen-4; MM, multiple myeloma.