Table 3.

Summary of Total Resource Utilization Counts and Cost Over the Observational Period

Healthcare Resource	Pretreatment†	Posttreatment	Change	P value
Emergency department visits
Proportion of patients with one or more	54.3%	31.7%	−22.6%	<.001
Total count	385	174	−211	—
Mean (range) number of visits	1.67 (0-18)	0.76 (0-17)	−0.92 ± 2.04‡	<.001
Estimated cost/patient	$791.28	$360.10	−$431.18§	—
Urgent care visits
Proportion of patients with one or more	20.2%	9.6%	−10.6%	.061
Total count	150	61	−89	—
Mean (range) number of visits	0.65 (0-12)	0.27 (0-8)	−0.39 ± 1.46‡	<.001
Estimated cost/patient	$84.68	$35.18	−$49.50§	—
Hospitalizations
Proportion of patients with one or more	15.7%	7.4%	8.3%	.013
Total count	45	19	−26	—
Mean (range) number of visits	0.20 (0-5)	0.08 (0-2)	−0.11 ± 0.55‡	.002
Estimated cost/patient	$1231.08	$492.43	−$738.65§	—
OnabotulinumtoxinA
Estimated cost/patient	$0	$2451.02	+$2451.02	—
Net cost/patient
Net cost	—	—	+$1219.33	—
% Cost offset	—	—	49.7%	—

^†Pretreatment values were obtained through patient recall of the previous 6 months. Healthcare resource utilization in the 6 months prior to initiation of treatment with onabotulinumtoxinA was compared with the subsequent 6 months by calculating a mean per-patient reduction as well as the incident event rate ratio for each type of healthcare resource utilization.

^‡Mean reduction in visits rounded to the nearest hundredth ± standard deviation.

^§Calculated by the mean reduction in visits multiplied by the unit cost of each healthcare resource.

— = not applicable.