Table 2.
Criteria of dialyzability
| Dialyzabilitya | Primary criteria | Alternative criteria 1 | Alternative criteria 2 | Alternative criteria 3 |
|---|---|---|---|---|
| % Removedb | CLEC/CLTOT (%)c | T1/2 EC/T1/2 (%) | ReEC/ReTOT (%)c | |
| D, Dialyzable | >30 | >75 | <25 | >75 |
| M, Moderately dialyzable | >10–30 | >50–75 | >25–50 | >50–75 |
| S, Slightly dialyzable | ≥3–10 | ≥25–50 | ≥50–75 | ≥25–50 |
| N, Not dialyzable | <3 | <25 | >75 | <25 |
a
Applicable to all modalities of ECTR, including hemodialysis, hemoperfusion, hemofiltration.
b
Corresponds to% removal of ingested dose or total body burden in a 6-hour ECTR period.
c
Measured during the same period of time.
These criteria should only be applied if measured or calculated (not reported) endogenous half-life is >4 hours (otherwise, ECTR is considered not clinically relevant). Furthermore, the primary criterion is preferred for poisons having a large Vd (>5 l/kg). Obtained with permission from Clinical Toxicology.