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. Author manuscript; available in PMC: 2016 Jan 2.
Published in final edited form as: Circ Res. 2014 Oct 16;116(1):167–182. doi: 10.1161/CIRCRESAHA.116.303554

Figure 6. Dual roles of Mfn2 in mitochondrial fusion and mitophagy.

Figure 6

Left – Non-phosphorylated Mfn2 provokes tethering and fusion of normal (hyperpolarized) mitochondria. Right – PINK1-phosphorylated Mfn2 acts as a receptor that attracts Parkin to depolarized mitochondria (in which PINK1 protein is stabilized), initiating ubiquitylation of mitochondrial outer membrane proteins that recruits autophagosomes.